Fruit Peels of Citrus Tangerina Attenuate the Oxidative Stress and Cell Damage Caused by Paracetamol on Wistar Rats
Antioxidant effect of Fruit Peels of Citrus Tangerina
Keywords:
paracetamol, Citrus tangerina, flavonoid, antioxidantsAbstract
Introduction: The regulation of the physiological processes in the body is one of the vital roles of the liver. Hepatic damage or liver dysfunction is a major health concern in the society. the need to explore alternative drugs for the treatment of hepatic diseases necessitated the present study of the effect of fruit peels extract of Citrus tangerina on paracetamol-induced hepatotoxicity in Wistar rats.
Materials and methods: Animals were grouped as follows: group I received normal diet, group II was given paracetamol 500 mg/kg/day, groups III and IV received fruit peel extracts of Citrus tangerina at 200 and 400 mg/kg/day respectively, while group V received silymarin 100 mg/kg/day (standard drug). Groups III-V were simultaneously administered paracetamol 500 mg/kg/day to induce hepatotoxicity. All drugs were given orally. At the end of a 7-days experimental period, the animals’ serum and liver were obtained for biochemical and histopathological analyses.
Results: Results of this study showed that paracetamol dosing increased serum AST (aspartate transaminase), ALT (alanine transaminase) and ALP (alkaline phosphatase), as well as decreased antioxidant enzymes. Treatment with C. tangerina fruit peel extract significantly reversed paracetamol hepatotoxic effect in a dose-dependent manner.
Conclusion: This study suggests that C. tangerina fruit peel extract possesses antioxidant property and attenuates liver damage induced by paracetamol in Wistar rats.
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