Histological Effects of Chronic Consumption of Soft Drinks on the Intracranial Visual Relay Centres of Adult Wistar Rats
Keywords:
superior colliculus, lateral geniculate bodyAbstract
Background: Effects of chronic consumption of cola drinks on the intracranial visual relay centres namely superior colliculus and lateral geniculate body of adult wistar rats were studied.
Methods: Rats of both sexes with average weight of 200g were equally assigned into three groups of n=8 each. The rats in groups [A] and [B] were respectively given [Brand A] and [Brand B] of different brands of cola drink for thirty days liberally. The group C (control) received equal volume of distilled water as placebo for the same period. On day thirty-one of the experiment, the animals were sacrificed by cervical dislocation. The superior colliculus and lateral geniculate body were carefully dissected out and quickly fixed in 10% formal saline for histological study.
Results: The rats in the treated groups showed some cellular degenerative changes, hypertrophy, sparse cellular population, pyknotic nuclei with some microcystic changes, edema and vacuolation in the stroma of the superior colliculus and lateral geniculate body as compared to the control group.
Conclusion: Chronic consumption of cola drinks may therefore have adverse effect on visual sensibilities by affecting the microanatomy of the superior colliculus and lateral geniculate body. It is recommended that further studies aimed at corroborating these observations be carried out.
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